First results of a comprehensive study analyzing activity of all human genes in malignant melanoma have been published. The scientific aim of this study is the identification of a „genetic fingerprint” of tumor aggressiveness. In clinical practice, this knowledge could enable prediction of tumor relapse, at the time of first diagnosis (melanoma prognosis). The study is carried out at one of Germany’s largest skin cancer centers and builds on a comprehensive biobank of tumor tissue and clinical data, collected over a period of 20 years. The initial findings indicate feasibility of the study and allow first insights into prognostically relevant genes for malignant melanoma.